BroccoBoost

Cancer-fighting
In laboratory tests, sulforaphane is shown to stimulate the production of enzymes in the body that detoxify cancer-causing substances BEFORE they have a chance to damage cells. Sulforaphane is show to protect against cancer via multiple pathways and at several stages of cancer development (Anand et al., 2008).

Sulforaphane can simultaneously inhibition enzymes that are responsible for the activation of pro-carcinogens and trigger enzymes that are vital in eliminating mutations. Sulforaphane is involved in multiple anti-cancer pathways, including inducing apoptosis (cancer cell death), induction of cell cycle arrest, and inhibition of NFκB (Tortorella et al., 2015).
Anti-inflammatory
Sulforaphane inhibits multiple types of inflammasones and can improve a variety of inflammation-based diseases such as inflammatory bowel disease (IBD), Type 1 and Type 2 diabetes, atherosclerosis, respiratory conditions such as asthma and certain autoimmune disorders (Greaney et al., 2016).
Neuroprotective
Sulforaphane is packed with antioxidant and anti-inflammatory phytochemicals that are shown to help prevent brain diseases and have a neuroprotective effect. Sulforaphane is able to cross the blood-brain barrier and accumulate in cerebral tissues and the central nervous system, where it activates the Nrf2 signaling pathway as well as antioxidative and antoxic enzymes (Sun et al., 2017).
Anti-diabetic
When comparing sulforaphane to 3,800 drugs, sulforaphane was found to best reverse the disease signature in liver tissue for Type2 diabetes. Sulforaphane suppressed the production of glucose from liver cells via the Nrf2 pathway and reduced the expression of key enzymes involved in gluconeogenesis (the production of glucose from certain non-carbohydrate substrates). In animal studies, sulforaphane reversed the disease signature in the livers from diabetic animals and performed similar to metformin in its ability to reduce the effect of exaggerated glucose production and glucose intolerance. As part of a concentrated broccoli sprout extract, sulforaphane was also able to decrease fasting blood glucose and glycated hemoglobin (HbA1c) levels in obese patients with dysregulated Type 2 diabetes (Axelsson et al., 2017).
Liver-protective
In a randomized, placebo-controlled, double blind trial involving, male participants with fatty liver disease were give either broccoli sprout capsules containing glucoraphanin or a placebo for two months. The patients give the broccoli sprout extract had significantly decreased serum levels of liver function markers, including ALT, γ-GTP and alkali phosphatase, while the placebo group showed no significant effects on the markers (Kikuchi et al., 2015).

Broccoli sprout extract also prevented chronic liver failure in rats injected with a known liver toxin and carcinogen. The protective effect was attributed to inducing phase 2 antioxidant enzymes, including hepatic glutathione S-transferase, involved in detoxification (Kikuchi et al., 2015).
Defends Against Gut Pathogens
Studies show that sulforaphane can help kill H. Pylori in the gut, with high effectiveness against bacterial strains resistant to the antibiotics clarithromycin and metronidazole (Fahey et al., 2002; Romeo et al., 2018). Research also shows that natural sulforaphane induced eradication of H. pylori infections from human gastric xenografts implanted in nude mice. Of 11 implanted xenografts treated with sulforaphane, eight were completely eradicated of the H. pylori infections (Haristoy et al, 2003; Romeo et al., 2018).

How should I store BroccoBoost?
To maintain the efficacy and freshness of the product, store it at room temperature and out of direct sunlight. Be sure to avoid exposing it to moisture. Do not refrigerate BroccoBoost, as this will encourage moisture to form.
How do I give it to my dog?
Simply mix BroccoBoost into your dog's regular meal or sprinkle it on top for a fabulous nutritional boost.
How long will it last my dog?
A 1-ounce package, as dosed above, will last a tiny dog about 13 months, a small dog about 6 1/2 months, a medium-sized dog about 3 1/3 months and a large dog about 1 1/2 months.

However, bear in mind that to maintain optimal freshness and efficacy, we recommend replacing the product every 3 months. If you have a tiny or small dog, there will be plenty left to share!
What is the refund policy?
I want you to be 100% satisfied. If you are not for any reason, please reach out to me within 30 days for a full refund.
Can people take BroccoBoost?
Absolutely! BroccoBoost is a 100% human-grade product that ALSO benefits our canine companions! A typical dosage for people is 1 teaspoon per day mixed into water or a smoothie or sprinkled on top of your snack or meal. Always start out slowly and increase the daily amount based on your individual tolerance.
Can hypothyroid dogs and people use it?
Research on the effects of broccoli sprouts and thyroid function are limited. According to a 2019 study, "Broccoli sprouts have been confirmed not to have any harmful effects on the thyroid homeostasis in animals in terms of TSH, fT3 and fT4 levels which remained unchanged. For animals with hypothyroidism, broccoli sprouts exert a beneficial influence on the antioxidant balance of the thyroid gland" (Pasko et al., 2018).

However, broccoli is a goitrogenic food, meaning that it can further impair thyroid function in hypothyroid individuals. For that reason, I advice consulting with your veterinarian or medical provider before taking BroccoBoost if you or your dog suffer from hypothyroidism.
Are there risks to sulforaphane?
As with other sulforaphane-rich cruciferous veggies, the most common undesirable side effect of broccoli sprouts is gastrointestinal issues such as gas, bloating and loose stool. This is why it is essential to start off slowly (I recommend starting at one-third the recommended dose and working your way up) and to not overdo it. If you notice that your dog is having any unwanted gastrointestinal effects, be sure to reduce the amount you give. Remember that more is not always better! This is a raw, living food so only a little is needed to achieve the beneficial effects (Robbins, 2020).

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Statements on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure or prevent any disease in humans or animals. Information on this site is provided for informational purposes only. It is not meant to substitute for veterinary or medical advice. You should not use the information contained herein for diagnosing or treating a health problem or disease in your dog or yourself, or prescribing any medication. Carefully read all product documentation. If you suspect that your dog (or yourself) has a medical problem, promptly contact your dog's (or your own) regular health care provider.

Cited Sources

Anand, P., Kunnumakara, A.B., Sundaram, C. et al. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharm Res 25, 2097–2116 (2008). https://doi.org/10.1007/s11095-008-9661-9

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y, Fahey JW, Derry JMJ, Wollheim CB, Wierup N, et al.. (2017). Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine. https://www.science.org/doi/10.1126/scitranslmed.aah4477

Fahey, J. W., Haristoy, X., Dolan, P. M., Kensler, T. W., Scholtus, I., Stephenson, K. K., Talalay, P., & Lozniewski, A. (2002). Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7610–7615. https://doi.org/10.1073/pnas.112203099

Greaney, A. J., Maier, N. K., Leppla, S. H., & Moayeri, M. (2016). Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. Journal of leukocyte biology, 99(1), 189–199. https://doi.org/10.1189/jlb.3A0415-155RR Haristoy, X., Angioi-Duprez, K., Duprez, A., & Lozniewski, A. (2003). Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice. Antimicrobial agents and chemotherapy, 47(12), 3982–3984. https://doi.org/10.1128/AAC.47.12.3982-3984.2003

Kikuchi, M., Ushida, Y., Shiozawa, H., Umeda, R., Tsuruya, K., Aoki, Y., Suganuma, H., & Nishizaki, Y. (2015). Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World journal of gastroenterology, 21(43), 12457–12467. https://doi.org/10.3748/wjg.v21.i43.12457

Paweł Paśko, Mirosław Krośniak, Ewelina Prochownik, Małgorzata Tyszka-Czochara, Maria Fołta, Renata Francik, Jakub Sikora, Mateusz Malinowski, Paweł Zagrodzki, Effect of broccoli sprouts on thyroid function, haematological, biochemical, and immunological parameters in rats with thyroid imbalance, Biomedicine & Pharmacotherapy, Volume 97, 2018, Pages 82-90, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2017.10.098.

Robbins, O. (2020). What is Sulforaphane - And why is it so Good for You? https://foodrevolution.org/blog/what-is-sulforaphane/ Romeo, L., Iori, R., Rollin, P., Bramanti, P., & Mazzon, E. (2018). Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections. Molecules (Basel, Switzerland), 23(3), 624. https://doi.org/10.3390/molecules23030624

Sun, Y., Yang, T., Mao, L., & Zhang, F. (2017). Sulforaphane Protects against Brain Diseases: Roles of Cytoprotective Enzymes. Austin journal of cerebrovascular disease & stroke, 4(1), 1054. https://doi.org/10.26420/austinjcerebrovascdisstroke.2017.1054

Tortorella, S. M., Royce, S. G., Licciardi, P. V., & Karagiannis, T. C. (2015). Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxidants & redox signaling, 22(16), 1382–1424. https://doi.org/10.1089/ars.2014.6097

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